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Abstract Fluids are commonly invoked as the primary cause for weakening of detachment shear zones. However, fluid-related mechanisms such as pressure-solution, reaction-enhanced ductility, reaction softening and precipitation of phyllosilicates are not fully understood. Fluid-facilitated reaction and mass transport cause rheological weakening and strain localization, eventually leading to departure from failure laws derived in laboratory experiments. This study focuses on the Miocene Raft River detachment shear zone in northwestern Utah. The shear zone is localized in the Proterozoic Elba Quartzite, which unconformably overlies the Archaean basement, and consists of an alternating sequence of quartzite and muscovite-quartzite schist. In this study, we characterize fluid-related microstructures to constrain conditions that promoted brittle failure in a plastically deforming shear zone. Thin-section analyses reveal the presence of healed microcracks, transgranular fluid inclusion planes and grain boundary fluid inclusion clusters. Healed microcracks occur in three sets, one sub-perpendicular to the mylonitic foliation, and a set of two conjugate microcracks oriented at ∼40–60° to the mylonitic foliation. Healed microfractures are filled with quartz, which has a distinct fabric, suggesting that microcracks healed while the shear zone was still at conditions favourable for quartz crystal plasticity. Transgranular fluid inclusion planes also occur in three sets, similar in orientation to the healed microfractures. Fluid inclusions commonly decorate grain and subgrain boundaries as inter- and intragranular clusters. Our results document ductile overprint of brittle microstructures, suggesting that, during exhumation, the Raft River detachment shear zone crossed the brittle–ductile transition repeatedly, providing pathways for fluids to permeate through this shear zone.